Kuk-Wha Lee, M.D. [ Edit Your Profile ]

Work Email Address:

Work Phone Number: (310) 825-0867

Mailing Address:
BOX 951752, 22-315 MDCC
Los Angeles, CA 90095

Assistant Professor, Pediatrics
Member, Center for Duchenne Muscular Dystrophy, JCCC Cancer and Stem Cell Biology Program Area, Pediatric Neuro-oncology and Neural Tumors Center
Assistant Professor In-Residence, Pediatric Endocrinology

M.D., Loma Linda University School of Medicine, 1996
2000 - 2003 UCLA School of Medicine
1997 - 1998 Loma Linda Univ. Childrens Hospital
1998 - 2000 Loma Linda Univ. Childrens Hospital

2005 American Board of Pediatrics
2000 American Board of Pediatrics

Seligson David B, Yu Hong, Tze Sheila, Said Jonathan, Pantuck Allan J, Cohen Pinchas, Lee Kuk-Wha, IGFBP-3 Nuclear Localization Predicts Human Prostate Cancer Recurrence. Hormones & cancer. 2013; 4(1): 12-23.
Mehta Hemal H, Gao Qinglei, Galet Colette, Paharkova Vladislava, Wan Junxiang, Said Jonathan, Sohn Joanne J, Lawson Gregory, Cohen Pinchas, Cobb Laura J, Lee Kuk-Wha, IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer research. 2011; 71(15): 5154-63.
Paharkova-Vatchkova Vladislava, Lee Kuk-Wha, Nuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties. Endocrine-related cancer. 2010; 17(2): 293-302.
Hoang Phuong T, Park Patricia, Cobb Laura J, Paharkova-Vatchkova Valdislava, Hakimi Michael, Cohen Pinchas, Lee Kuk-Wha, The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism: clinical and experimental. 2010; 59(3): 343-9.
Jia Yue, Lee Kuk-Wha, Swerdloff Ronald, Hwang David, Cobb Laura J, Sinha Hikim Amiya, Lue Yan He, Cohen Pinchas, Wang Christina, Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. The Journal of biological chemistry. 2010; 285(3): 1726-32.
Lue YanHe, Swerdloff Ronald, Liu QingHai, Mehta Hemal, Hikim Amiya Sinha, Lee Kuk-Wha, Jia Yue, Hwang David, Cobb Laura J, Cohen Pinchas, Wang Christina, Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010; 151(1): 350-7.
Yamada Paulette M, Lee Kuk-Wha, Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. American journal of physiology. Cell physiology. 2009; 296(5): C954-76.
Hoftman Alice Chang, Hernandez Maria I, Lee Kuk-Wha, Stiehm E Richard, Newborn illnesses caused by transplacental antibodies. Advances in pediatrics. 2008; 55(5): 271-304.
Lee Kuk-Wha, Cobb Laura J, Paharkova-Vatchkova Vladislava, Liu Bingrong, Milbrandt Jeffrey, Cohen Pinchas, Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007; 28(8): 1653-8.
Kim Hae Soon, Ali Omar, Shim Melanie, Lee Kuk-Wha, Vuguin Patricia, Muzumdar Radhika, Barzilai Nir, Cohen Pinchas, Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatric research. 2007; 61(2): 159-64.
Cobb Laura J, Liu Bingrong, Lee Kuk-Wha, Cohen Pinchas, Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer research. 2006; 66(22): 10878-84.
Liu Bingrong, Lee Kuk-Wha, Li Heju, Ma Liqun, Lin George L, Chandraratna Roshantha A S, Cohen Pinchas, Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(13): 4851-6.
Lee Kuk-Wha, Ma Liqun, Yan Xinmin, Liu Bingrong, Zhang Xiao-kun, Cohen Pinchas, Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. The Journal of biological chemistry. 2005; 280(17): 16942-8.
Lee Kuk-Wha, Lee Phillip D K, Growth hormone deficiency (GHD): a new association in Peters' Plus Syndrome (PPS). American journal of medical genetics. Part A. 2004; 124A(4): 388-91.
Lee Kuk-Wha, Liu Bingrong, Ma Liqun, Li Heju, Bang Peter, Koeffler H Phillip, Cohen Pinchas, Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. The Journal of biological chemistry. 2004; 279(1): 469-76.
Ikonen Maaria, Liu Bingrong, Hashimoto Yuichi, Ma Liqun, Lee Kuk-Wha, Niikura Takako, Nishimoto Ikuo, Cohen Pinchas, Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22): 13042-7.
Lee Kuk-Wha, Cohen Pinchas, Individualized growth hormone therapy in children: advances beyond weight-based dosing. Journal of pediatric endocrinology & metabolism : JPEM. 2003; 16 Suppl 3(22): 625-30.
Rajah Roopmathy, Lee Kuk-Wha, Cohen Pinchas, Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2002; 13(4): 163-71.