Directory

Stephen Caldwell Cannon, M.D., Ph.D. [ Edit Your Profile ]

Email Address: sccannon@mednet.ucla.edu

Work
Position/Title
Chair, Physiology
Member, CTSI, Molecular, Cellular & Integrative Physiology GPB Home Area

Education:
Degrees:
M.D.
Ph.D.

Publications

A selected list of publications:

Cannon Stephen C   Channelopathies of skeletal muscle excitability Comprehensive Physiology, 2015; 5(2): 761-90.
Mi Wentao, Rybalchenko Volodymyr, Cannon Stephen C   Disrupted coupling of gating charge displacement to Na+ current activation for DIIS4 mutations in hypokalemic periodic paralysis The Journal of general physiology, 2014; 144(2): 137-45.
Trivedi Jaya R, Cannon Stephen C, Griggs Robert C   Nondystrophic myotonia: challenges and future directions Experimental neurology, 2014; 253(2): 28-30.
Wu Fenfen, Mi Wentao, Cannon Stephen C   Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis Brain : a journal of neurology, 2013; 136(Pt 12): 3766-74.
Nelson Benjamin R, Wu Fenfen, Liu Yun, Anderson Douglas M, McAnally John, Lin Weichun, Cannon Stephen C, Bassel-Duby Rhonda, Olson Eric N   Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(29): 11881-6.
Wu Fenfen, Mi Wentao, Cannon Stephen C   Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis Neurology, 2013; 80(12): 1110-6.
Wu Fenfen, Mi Wentao, Hernández-Ochoa Erick O, Burns Dennis K, Fu Yu, Gray Hillery F, Struyk Arie F, Schneider Martin F, Cannon Stephen C   A calcium channel mutant mouse model of hypokalemic periodic paralysis The Journal of clinical investigation, 2012; 122(12): 4580-91.
Cannon Stephen C   Small fiber neuropathy: a bit less idiopathic? Neurology, 2012; 78(21): 1626-7.
Wu Fenfen, Mi Wentao, Burns Dennis K, Fu Yu, Gray Hillery F, Struyk Arie F, Cannon Stephen C   A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis The Journal of clinical investigation, 2011; 121(10): 4082-94.
Kudryashova Elena, Struyk Arie, Mokhonova Ekaterina, Cannon Stephen C, Spencer Melissa J   The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype Human molecular genetics, 2011; 20(20): 3925-32.
Cheng Chih-Jen, Lin Shih-Hua, Lo Yi-Fen, Yang Sung-Sen, Hsu Yu-Juei, Cannon Stephen C, Huang Chou-Long   Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis The Journal of biological chemistry, 2011; 286(31): 27425-35.
Francis David G, Rybalchenko Volodymyr, Struyk Arie, Cannon Stephen C   Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotonia Neurology, 2011; 76(19): 1635-41.
Cannon Stephen C   Voltage-sensor mutations in channelopathies of skeletal muscle The Journal of physiology, 2010; 588(Pt 11): 1887-95.
Cannon Stephen C, Bean Bruce P   Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies The Journal of clinical investigation, 2010; 120(1): 80-3.
Matthews E, Fialho D, Tan S V, Venance S L, Cannon S C, Sternberg D, Fontaine B, Amato A A, Barohn R J, Griggs R C, Hanna M G, Hanna M G   The non-dystrophic myotonias: molecular pathogenesis, diagnosis and treatment Brain : a journal of neurology, 2010; 133(Pt 1): 9-22.
Cannon Stephen C   Getting a charge out of periodic paralysis? Neurology, 2009; 72(18): 1540-1.
Webb Jadon, Wu Fen-fen, Cannon Stephen C   Slow inactivation of the NaV1.4 sodium channel in mammalian cells is impeded by co-expression of the beta1 subunit Pflügers Archiv : European journal of physiology, 2009; 457(6): 1253-63.
Struyk Arie F, Markin Vladislav S, Francis David, Cannon Stephen C   Gating pore currents in DIIS4 mutations of NaV1.4 associated with periodic paralysis: saturation of ion flux and implications for disease pathogenesis The Journal of general physiology, 2008; 132(4): 447-64.
Hayward Lawrence J, Kim Joanna S, Lee Ming-Yang, Zhou Hongru, Kim Ji W, Misra Kumudini, Salajegheh Mohammad, Wu Fen-fen, Matsuda Chie, Reid Valerie, Cros Didier, Hoffman Eric P, Renaud Jean-Marc, Cannon Stephen C, Brown Robert H   Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness The Journal of clinical investigation, 2008; 118(4): 1437-49.
Webb Jadon, Cannon Stephen C   Cold-induced defects of sodium channel gating in atypical periodic paralysis plus myotonia Neurology, 2008; 70(10): 755-61.
Struyk Arie F, Cannon Stephen C   A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore The Journal of general physiology, 2007; 130(1): 11-20.
Cannon Stephen C   Physiologic principles underlying ion channelopathies Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2007; 4(2): 174-83.
Cannon Stephen C   Pathomechanisms in channelopathies of skeletal muscle and brain Annual review of neuroscience, 2006; 29(2): 387-415.
Venance S L, Cannon S C, Fialho D, Fontaine B, Hanna M G, Ptacek L J, Tristani-Firouzi M, Tawil R, Griggs R C, Griggs R C   The primary periodic paralyses: diagnosis, pathogenesis and treatment Brain : a journal of neurology, 2006; 129(Pt 1): 8-17.
Wu Fen-fen, Gordon Erynn, Hoffman Eric P, Cannon Stephen C   A C-terminal skeletal muscle sodium channel mutation associated with myotonia disrupts fast inactivation The Journal of physiology, 2005; 565(Pt 2): 371-80.
Berg Jim, Jiang Hong, Thornton Charles A, Cannon Stephen C   Truncated ClC-1 mRNA in myotonic dystrophy exerts a dominant-negative effect on the Cl current Neurology, 2004; 63(12): 2371-5.
Cannon Stephen C   Paying the price at the pump: dystonia from mutations in a Na+/K+ -ATPase Neuron, 2004; 43(2): 153-4.
Tsujino Akira, Maertens Chantal, Ohno Kinji, Shen Xin-Ming, Fukuda Taku, Harper C Michael, Cannon Stephen C, Engel Andrew G   Myasthenic syndrome caused by mutation of the SCN4A sodium channel Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(12): 7377-82.
Struyk Arie F, Cannon Stephen C   Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels The Journal of general physiology, 2002; 120(4): 509-16.
Cannon Stephen C   An expanding view for the molecular basis of familial periodic paralysis Neuromuscular disorders : NMD, 2002; 12(6): 533-43.
Mankodi Ami, Takahashi Masanori P, Jiang Hong, Beck Carol L, Bowers William J, Moxley Richard T, Cannon Stephen C, Thornton Charles A   Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy Molecular cell, 2002; 10(1): 35-44.
Cannon Stephen C   Sodium channel gating: no margin for error Neuron, 2002; 34(6): 853-4.
Takahashi M P, Cannon S C   Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na(+) channel The Journal of physiology, 2001; 537(Pt 3): 701-14.
Wu F F, Takahashi M P, Pegoraro E, Angelini C, Colleselli P, Cannon S C, Hoffman E P   A new mutation in a family with cold-aggravated myotonia disrupts Na(+) channel inactivation Neurology, 2001; 56(7): 878-84.
Struyk A F, Scoggan K A, Bulman D E, Cannon S C   The human skeletal muscle Na channel mutation R669H associated with hypokalemic periodic paralysis enhances slow inactivation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000; 20(23): 8610-7.
Ranganathan R, Cannon S C, Horvitz H R   MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans Nature, 2000; 408(6811): 470-5.
Morrill J A, Cannon S C   COOH-terminal truncated alpha(1S) subunits conduct current better than full-length dihydropyridine receptors The Journal of general physiology, 2000; 116(3): 341-8.
Vedantham V, Cannon S C   Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels Biophysical journal, 2000; 78(6): 2943-58.
Hayward L J, Sandoval G M, Cannon S C   Defective slow inactivation of sodium channels contributes to familial periodic paralysis Neurology, 1999; 52(7): 1447-53.
Takahashi M P, Cannon S C   Enhanced slow inactivation by V445M: a sodium channel mutation associated with myotonia Biophysical journal, 1999; 76(2): 861-8.
Vedantham V, Cannon S C   The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels The Journal of general physiology, 1999; 113(1): 7-16.
Morrill J A, Brown R H, Cannon S C   Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998; 18(24): 10320-34.
Green D S, George A L, Cannon S C   Human sodium channel gating defects caused by missense mutations in S6 segments associated with myotonia: S804F and V1293I The Journal of physiology, 1998; 510 ( Pt 3)(24): 685-94.
Vedantham V, Cannon S C   Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels The Journal of general physiology, 1998; 111(1): 83-93.
Green D S, Hayward L J, George A L, Cannon S C   A proposed mutation, Val781Ile, associated with hyperkalemic periodic paralysis and cardiac dysrhythmia is a benign polymorphism Annals of neurology, 1997; 42(2): 253-6.
Cannon S C   From mutation to myotonia in sodium channel disorders Neuromuscular disorders : NMD, 1997; 7(4): 241-9.
Hayward L J, Brown R H, Cannon S C   Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis Biophysical journal, 1997; 72(3): 1204-19.
Grosson C L, Cannon S C, Corey D P, Gusella J F   Sequence of the voltage-gated sodium channel beta1-subunit in wild-type and in quivering mice Brain research. Molecular brain research, 1996; 42(2): 222-6.
Cannon S C   Slow inactivation of sodium channels: more than just a laboratory curiosity Biophysical journal, 1996; 71(1): 5-7.
Hayward L J, Brown R H, Cannon S C   Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker The Journal of general physiology, 1996; 107(5): 559-76.
Cannon S C   Sodium channel defects in myotonia and periodic paralysis Annual review of neuroscience, 1996; 19(5): 141-64.
Cannon S C   Ion-channel defects and aberrant excitability in myotonia and periodic paralysis Trends in neurosciences, 1996; 19(1): 3-10.
Chen C, Cannon S C   Modulation of Na+ channel inactivation by the beta 1 subunit: a deletion analysis Pflügers Archiv : European journal of physiology, 1995; 431(2): 186-95.
Cannon S C, Hayward L J, Beech J, Brown R H   Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis Journal of neurophysiology, 1995; 73(5): 1892-9.
Cannon S C, Brown R H, Corey D P   Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels Biophysical journal, 1993; 65(1): 270-88.
Strittmatter S M, Cannon S C, Ross E M, Higashijima T, Fishman M C   GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes Proceedings of the National Academy of Sciences of the United States of America, 1993; 90(11): 5327-31.
McClatchey A I, Cannon S C, Slaugenhaupt S A, Gusella J F   The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain Human molecular genetics, 1993; 2(6): 745-9.
Cannon S C, McClatchey A I, Gusella J F   Modification of the Na+ current conducted by the rat skeletal muscle alpha subunit by coexpression with a human brain beta subunit Pflügers Archiv : European journal of physiology, 1993; 423(1-2): 155-7.
Cannon S C, Heacock D M   Incorporating peer review in performance appraisal Nursing management, 1991; 22(5): 88, 90.
Cannon S C, Miller J M, Crowther J, Moscow D   Effect of electrical stimulation on middle latency response in the guinea pig American journal of otolaryngology, 1991; 11(4): 251-5.
Jyung R W, Miller J M, Cannon S C   Evaluation of eighth nerve integrity by the electrically evoked middle latency response Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1989; 101(6): 670-82.
Crowther J, Cannon S C, Miller J M, Jyung R W, Kileny P   Anesthesia effects on the electrically evoked middle latency response in guinea pigs Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1989; 101(1): 51-5.
Kartush J M, Cannon S C, Bojrab D I, Graham M D, Schmaltz S, Kemink J L   Use of bacitracin for neurotologic surgery The Laryngoscope, 1988; 98(10): 1050-4.
Cannon S C, Niparko J K   Pathologic quiz case 1. Lingual osteoma Archives of otolaryngology--head & neck surgery, 1988; 114(1): 92-4.
Cannon S C, Robinson D A   Loss of the neural integrator of the oculomotor system from brain stem lesions in monkey Journal of neurophysiology, 1987; 57(5): 1383-409.
Cannon S C, Leigh R J, Zee D S, Abel L A   The effect of the rotational magnification of corrective spectacles on the quantitative evaluation of the VOR Acta oto-laryngologica, 1987; 100(1-2): 81-8.
Cannon S C, Robinson D A, Shamma S   A proposed neural network for the integrator of the oculomotor system Biological cybernetics, 1983; 49(2): 127-36.
Cannon S C, Zahalak G I   The mechanical behavior of active human skeletal muscle in small oscillations Journal of biomechanics, 1982; 15(2): 111-21.