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Kuk-Wha Lee, M.D. [ Edit Your Profile ]

Work Email Address: kukwhalee@mednet.ucla.edu

Work Phone Number: (310) 825-0867

Mailing Address:
BOX 951752, 22-315 MDCC
Los Angeles, CA 90095

Work
Position/Title
Assistant Professor, Pediatrics
Member, Center for Duchenne Muscular Dystrophy, JCCC Cancer and Stem Cell Biology Program Area, Pediatric Neuro-oncology and Neural Tumors Center
Assistant Professor In-Residence, Pediatric Endocrinology

Education:
Degrees:
M.D., Loma Linda University School of Medicine, 1996
Fellowship:
2000 - 2003 UCLA School of Medicine
Internship:
1997 - 1998 Loma Linda Univ. Childrens Hospital
Residency:
1998 - 2000 Loma Linda Univ. Childrens Hospital

Certifications:
Certifications:
2005 American Board of Pediatrics
2000 American Board of Pediatrics

Publications
Seligson David B, Yu Hong, Tze Sheila, Said Jonathan, Pantuck Allan J, Cohen Pinchas, Lee Kuk-Wha, IGFBP-3 Nuclear Localization Predicts Human Prostate Cancer Recurrence. Hormones & cancer. 2013; 4(1): 12-23.
Mehta Hemal H, Gao Qinglei, Galet Colette, Paharkova Vladislava, Wan Junxiang, Said Jonathan, Sohn Joanne J, Lawson Gregory, Cohen Pinchas, Cobb Laura J, Lee Kuk-Wha, IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer research. 2011; 71(15): 5154-63.
Paharkova-Vatchkova Vladislava, Lee Kuk-Wha, Nuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties. Endocrine-related cancer. 2010; 17(2): 293-302.
Hoang Phuong T, Park Patricia, Cobb Laura J, Paharkova-Vatchkova Valdislava, Hakimi Michael, Cohen Pinchas, Lee Kuk-Wha, The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism: clinical and experimental. 2010; 59(3): 343-9.
Jia Yue, Lee Kuk-Wha, Swerdloff Ronald, Hwang David, Cobb Laura J, Sinha Hikim Amiya, Lue Yan He, Cohen Pinchas, Wang Christina, Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. The Journal of biological chemistry. 2010; 285(3): 1726-32.
Lue YanHe, Swerdloff Ronald, Liu QingHai, Mehta Hemal, Hikim Amiya Sinha, Lee Kuk-Wha, Jia Yue, Hwang David, Cobb Laura J, Cohen Pinchas, Wang Christina, Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010; 151(1): 350-7.
Yamada Paulette M, Lee Kuk-Wha, Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. American journal of physiology. Cell physiology. 2009; 296(5): C954-76.
Hoftman Alice Chang, Hernandez Maria I, Lee Kuk-Wha, Stiehm E Richard, Newborn illnesses caused by transplacental antibodies. Advances in pediatrics. 2008; 55(5): 271-304.
Lee Kuk-Wha, Cobb Laura J, Paharkova-Vatchkova Vladislava, Liu Bingrong, Milbrandt Jeffrey, Cohen Pinchas, Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007; 28(8): 1653-8.
Kim Hae Soon, Ali Omar, Shim Melanie, Lee Kuk-Wha, Vuguin Patricia, Muzumdar Radhika, Barzilai Nir, Cohen Pinchas, Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatric research. 2007; 61(2): 159-64.
Cobb Laura J, Liu Bingrong, Lee Kuk-Wha, Cohen Pinchas, Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer research. 2006; 66(22): 10878-84.
Liu Bingrong, Lee Kuk-Wha, Li Heju, Ma Liqun, Lin George L, Chandraratna Roshantha A S, Cohen Pinchas, Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(13): 4851-6.
Lee Kuk-Wha, Ma Liqun, Yan Xinmin, Liu Bingrong, Zhang Xiao-kun, Cohen Pinchas, Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. The Journal of biological chemistry. 2005; 280(17): 16942-8.
Lee Kuk-Wha, Lee Phillip D K, Growth hormone deficiency (GHD): a new association in Peters' Plus Syndrome (PPS). American journal of medical genetics. Part A. 2004; 124A(4): 388-91.
Lee Kuk-Wha, Liu Bingrong, Ma Liqun, Li Heju, Bang Peter, Koeffler H Phillip, Cohen Pinchas, Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. The Journal of biological chemistry. 2004; 279(1): 469-76.
Ikonen Maaria, Liu Bingrong, Hashimoto Yuichi, Ma Liqun, Lee Kuk-Wha, Niikura Takako, Nishimoto Ikuo, Cohen Pinchas, Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(22): 13042-7.
Lee Kuk-Wha, Cohen Pinchas, Individualized growth hormone therapy in children: advances beyond weight-based dosing. Journal of pediatric endocrinology & metabolism : JPEM. 2003; 16 Suppl 3(22): 625-30.
Rajah Roopmathy, Lee Kuk-Wha, Cohen Pinchas, Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2002; 13(4): 163-71.