Directory

Ming Guo, M.D., Ph.D. [ Edit Your Profile ]

Work Email Address: mguo@mednet.ucla.edu

Lab Number: 310-794-4851
Office Phone Number: 310-206-9406
Work Phone Number: (310) 794-1195

Laboratory Address:
Gonda 3309

Office Address:
Gonda 3357A

Work
Position/Title
Professor, Neurology, Molecular & Medical Pharmacology
Member, Brain Research Institute, CTSI, Cell & Developmental Biology GPB Home Area, Center for Duchenne Muscular Dystrophy, Center for Neurodegenerative Disease Studies, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area, themes

Education:
Degrees:
M.D., Fudan University (previously Shanghai Medicine University)
M.D., Shanghai Medical University, 1989
Ph.D., University of California, San Francisco, 1996
Fellowship:
2001 - 2002 UCLA School of Medicine
Internship:
1997 - 1998 UC Irvine Medical Center
Residency:
1998 - 2001 UCLA School of Medicine
1998 - UCLA School of Medicine

Certifications:
Certifications:
2013 - American Board of Psychiatry and Neurology
2003 American Board of Psychiatry and Neurology
Certification Type:
1999 - Medical Board of California

Publications
Zhang T, Mishra P, Hay BA, Chan D and Guo M, VCP inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. eLife. 2017; in press: .
Kandul, N.P., Zhang, T., Hay, B.A.*, and Guo, M* (equal contribution)., Selective removal of deletion-bearing mitochondrial DNA in heteroplastic Drosophila. Nature Communications. 2016; in press: .
Harteinstein, V.*, Cruz, L., Lovick, J.K., and Guo, M.* (co-correspondence) , Developmental analysis of the dopamine-containing neurons of the Drosophila brain. Journal of Comparative Neurology. 2016; .
Yun, J., Puri, R.*, Yang, H.*, Lizzio, M., Wu, C., Sheng, Z.H. and Guo, M., MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. eLife. 2014; 3(e01958): (equal contribution).
Dauer WT, Guo M. , Multiplying messages LRRK beneath Parkinson disease. Cell. 2014; 157: 291-293.
Dodson, M.W., Leung, L.K., Lone, M. Lizzio, M.A. and Guo, M., Novel alleles of the Drosophila LRRK2 homolog reveal a crucial role in endolysosomal functions and autophagy in vivo. Disease Models and Mechanisms. 2014; 7:: 1351-63.
Gross GG, Lone GM, Leung LK, Hartenstein V, Guo M., X11/Mint genes control polarized localization of axonal membrane proteins in vivo. J. Neurosci. . 2013; 33: 8575-8586 (cover story).
Guo, M. , Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease. Cold Spring Harb. Perspect. Med. 2012; a009944: .
M.W. Dodson, T. Zhang, C. Jiang, S. Chen and M. Guo, Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning. Human Molecular Genetics. 2012; 21: 1350-1363.
J.C. Rochet, B.A. Hay and M. Guo, Molecular Insights into Parkinson's Disease. Progress in Molecular Biology and Translational Science. 2012; 107: 125-188.
M. Guo, What have we learned from Drosophila models of Parkinson?s disease. Progress in Brain Research. 2010; 184: 3-17.
B.A. Hay, C.H. Chen, C. M. Ward, H. Huang. J. T.Su, and M. Guo , Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements. J. Insect Physiol. . 2010; 56: 1402-1413.
Li, H. and Guo, M., Protein Degradation in Parkinson Disease Revisited: It's Complex . J. Clinical Invest. 2009; 119: 442-445.
Deng, H. Dodson, M.W. Huang, H. Guo, M., The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or fusion in Drosophila. PNAS. 2008; 105: 14503-14508.
Yun, J. Cao, J.H. Dodson, M.W Clark, I.E. Kapahi, P. Chowdhury, R.B. and Guo, M., Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo. J. Neurosci. 2008; 28: 14500-14510.
Gross, G.G. Feldman, R. Ganguly, A. Wang, J. Yu, H. and Guo, M., Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila. PLoS ONE. 2008; 3: e2495.
Ganguly, A.*, Feldman, R.* and Guo, M., ubiquilin antagonizes presenilin and promotes neurodegeneration. Human Molecular Genetics. 2008; 17: 293-302. (Cover Story).
Chen, C., Huang, H., Ward, C., Su, J., Schaeffer, L., M. Guo and Hay, B.A., A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila . Science. 2007; 316: 597-600.
Dodson, M.W. and Guo, M. , Pink1, Parkin, DJ-1 and Mitochondrial Dysfunction in Parkinson's Disease. Curr. Opin. Neurobiol. 2007; 17: 331-337.
Clark, I.E*., Dodson, M.W.*, Jiang, C.*, Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. , Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin . Nature. 2006; 441: 1162-1166.
Hay, B.A. and Guo, M., Caspase-Dependent Cell Death in Drosophila. Annu. Rev. Cell Dev. Biol. 2006; 22: 623-650.
Hay, BA, Huh, JR and Guo, M, The genetics of cell death: approaches, insights and opportunities in Drosophila. Nature Review Genetics . 2004; 5(12): 911-22.
Xu P, Guo M, Hay BA., MicroRNAs and the regulation of cell death. Trends Genet. 2004; 20(12): 617-624.
Guo, M Hong, EJ Fernandes, J Zipursky, SL Hay, BA, A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Human molecular genetics. . 2003; 12(20): 2669-78.
Hay, BA Guo, M, Coupling cell growth, proliferation, and death. Hippo weighs in. Developmental cell. . 2003; 5(3): 361-3.
Xu, P Vernooy, SY Guo, M Hay, BA, The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Current biology : . 2003; 13(9): 790-5.
Guo, M., Hay, B., Cell proliferation and apoptosis. Curr Opin Cell Biol. . 1999; 11: 745-752.