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Loren G Fong, Ph.D. [ Edit Your Profile ]

Email Address: lfong@mednet.ucla.edu

Office Phone Number: (310) 825-4997

Department Address:
650 Charles E. Young Dr. South
CHS A2-237
Los Angeles, CA 90095

Office Address:
695 Charles E. Young Dr. South
Gonda 4506C
Los Angeles, CA 90095

Work
Position/Title
Professor In-Residence, Medicine
Member, Center for Duchenne Muscular Dystrophy, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, JCCC Signal Transduction and Therapeutics Program Area
Faculty, Cardiology

Education:
Degrees:
Ph.D., University of California, Los Angeles
B.Sc., University of California, Davis

Publications
Larsson Mikael, Allan Christopher M, Jung Rachel S, Heizer Patrick J, Beigneux Anne P, Young Stephen G, Fong Loren G, Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL. Journal of lipid research. 2017; 58(9): 1893-1902.
Allan Christopher M, Jung Cris J, Larsson Mikael, Heizer Patrick J, Tu Yiping, Sandoval Norma P, Dang Tiffany Ly P, Jung Rachel S, Beigneux Anne P, de Jong Pieter J, Fong Loren G, Young Stephen G, Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding. Journal of lipid research. 2017; 58(7): 1453-1461.
Beigneux Anne P, Miyashita Kazuya, Ploug Michael, Blom Dirk J, Ai Masumi, Linton MacRae F, Khovidhunkit Weerapan, Dufour Robert, Garg Abhimanyu, McMahon Maureen A, Pullinger Clive R, Sandoval Norma P, Hu Xuchen, Allan Christopher M, Larsson Mikael, Machida Tetsuo, Murakami Masami, Reue Karen, Tontonoz Peter, Goldberg Ira J, Moulin Philippe, Charrière Sybil, Fong Loren G, Nakajima Katsuyuki, Young Stephen G, Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. The New England journal of medicine. 2017; 376(17): 1647-1658.
He Cuiwen, Fong Loren G, Young Stephen G, Jiang Haibo, NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2017; 65(3): 669-672.
He Cuiwen, Hu Xuchen, Jung Rachel S, Weston Thomas A, Sandoval Norma P, Tontonoz Peter, Kilburn Matthew R, Fong Loren G, Young Stephen G, Jiang Haibo, High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(8): 2000-2005.
Allan Christopher M, Larsson Mikael, Jung Rachel S, Ploug Michael, Bensadoun André, Beigneux Anne P, Fong Loren G, Young Stephen G, Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries. Journal of lipid research. 2017; 58(1): 216-225.
Tu Yiping, Sánchez-Iglesias Sofía, Araújo-Vilar David, Fong Loren G, Young Stephen G, LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A. Nucleus (Austin, Tex.). 2016; 7(5): 512-521.
Fong Loren G, Young Stephen G, Beigneux Anne P, Bensadoun André, Oberer Monika, Jiang Haibo, Ploug Michael, GPIHBP1 and Plasma Triglyceride Metabolism. Trends in endocrinology and metabolism: TEM. 2016; 27(7): 455-69.
Razafsky David, Ward Candace, Potter Chloe, Zhu Wanqiu, Xue Yunlu, Kefalov Vladimir J, Fong Loren G, Young Stephen G, Hodzic Didier, Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development. Molecular biology of the cell. 2016; 27(12): 1928-37.
Lee John M, Nobumori Chika, Tu Yiping, Choi Catherine, Yang Shao H, Jung Hea-Jin, Vickers Timothy A, Rigo Frank, Bennett C Frank, Young Stephen G, Fong Loren G, Modulation of LMNA splicing as a strategy to treat prelamin A diseases. The Journal of clinical investigation. 2016; 126(4): 1592-602.
Vergnes Laurent, Chin Robert G, de Aguiar Vallim Thomas, Fong Loren G, Osborne Timothy F, Young Stephen G, Reue Karen, SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. Journal of lipid research. 2016; 57(3): 410-21.
Mysling Simon, Kristensen Kristian Kølby, Larsson Mikael, Beigneux Anne P, Gårdsvoll Henrik, Fong Loren G, Bensadouen André, Jørgensen Thomas Jd, Young Stephen G, Ploug Michael, The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain. eLife. 2016; 5(2): e12095.
Yang Shao H, Procaccia Shiri, Jung Hea-Jin, Nobumori Chika, Tatar Angelica, Tu Yiping, Bayguinov Yulia R, Hwang Sung Jin, Tran Deanna, Ward Sean M, Fong Loren G, Young Stephen G, Mice that express farnesylated versions of prelamin A in neurons develop achalasia. Human molecular genetics. 2015; 24(10): 2826-40.
Tapia Olga, Fong Loren G, Huber Michael D, Young Stephen G, Gerace Larry, Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PloS one. 2015; 10(3): e0116196.
Jung Hea-Jin, Tatar Angelica, Tu Yiping, Nobumori Chika, Yang Shao H, Goulbourne Chris N, Herrmann Harald, Fong Loren G, Young Stephen G, An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Molecular and cellular biology. 2014; 34(24): 4534-44.
Degagné Emilie, Pandurangan Ashok, Bandhuvula Padmavathi, Kumar Ashok, Eltanawy Abeer, Zhang Meng, Yoshinaga Yuko, Nefedov Mikhail, de Jong Pieter J, Fong Loren G, Young Stephen G, Bittman Robert, Ahmedi Yasmin, Saba Julie D, Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. The Journal of clinical investigation. 2014; 124(12): 5368-84.
Jiang Haibo, Goulbourne Chris N, Tatar Angelica, Turlo Kirsten, Wu Daniel, Beigneux Anne P, Grovenor Chris R M, Fong Loren G, Young Stephen G, High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis. Journal of lipid research. 2014; 55(10): 2156-66.
Young Stephen G, Jung Hea-Jin, Lee John M, Fong Loren G, Nuclear lamins and neurobiology. Molecular and cellular biology. 2014; 34(15): 2776-85.
Lee John M, Jung Hea-Jin, Fong Loren G, Young Stephen G, Do lamin B1 and lamin B2 have redundant functions?. Nucleus (Austin, Tex.). 2014; 5(4): 287-92.
Jiang H, Favaro E, Goulbourne C N, Rakowska P D, Hughes G M, Ryadnov M G, Fong L G, Young S G, Ferguson D J P, Harris A L, Grovenor C R M, Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques. Methods (San Diego, Calif.). 2014; 68(2): 317-24.
Lee John M, Tu Yiping, Tatar Angelica, Wu Daniel, Nobumori Chika, Jung Hea-Jin, Yoshinaga Yuko, Coffinier Catherine, de Jong Pieter J, Fong Loren G, Young Stephen G, Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Molecular biology of the cell. 2014; 25(10): 1666-75.
Goulbourne Chris N, Gin Peter, Tatar Angelica, Nobumori Chika, Hoenger Andreas, Jiang Haibo, Grovenor Chris R M, Adeyo Oludotun, Esko Jeffrey D, Goldberg Ira J, Reue Karen, Tontonoz Peter, Bensadoun André, Beigneux Anne P, Young Stephen G, Fong Loren G, The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell metabolism. 2014; 19(5): 849-60.
Jung Hea-Jin, Tu Yiping, Yang Shao H, Tatar Angelica, Nobumori Chika, Wu Daniel, Young Stephen G, Fong Loren G, New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome. Human molecular genetics. 2014; 23(6): 1506-15.
Csaki Lauren S, Dwyer Jennifer R, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen, Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Progress in lipid research. 2013; 52(3): 305-16.
Ibrahim Mohamed X, Sayin Volkan I, Akula Murali K, Liu Meng, Fong Loren G, Young Stephen G, Bergo Martin O, Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Science (New York, N.Y.). 2013; 340(6138): 1330-3.
Jung Hea-Jin, Nobumori Chika, Goulbourne Chris N, Tu Yiping, Lee John M, Tatar Angelica, Wu Daniel, Yoshinaga Yuko, de Jong Pieter J, Coffinier Catherine, Fong Loren G, Young Stephen G, Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(21): E1923-32.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter, IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Molecular and cellular biology. 2013; 33(8): 1503-14.
Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter, Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell metabolism. 2013; 17(3): 423-35.
Jung Hea-Jin, Lee John M, Yang Shao H, Young Stephen G, Fong Loren G, Nuclear lamins in the brain - new insights into function and regulation. Molecular neurobiology. 2013; 47(1): 290-301.
Young Stephen G, Yang Shao H, Davies Brandon S J, Jung Hea-Jin, Fong Loren G, Targeting protein prenylation in progeria. Science translational medicine. 2013; 5(171): 171ps3.
Davies Brandon S J, Goulbourne Chris N, Barnes Richard H, Turlo Kirsten A, Gin Peter, Vaughan Sue, Vaux David J, Bensadoun André, Beigneux Anne P, Fong Loren G, Young Stephen G, Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells. Journal of lipid research. 2012; 53(12): 2690-7.
Adeyo O, Goulbourne C N, Bensadoun A, Beigneux A P, Fong L G, Young S G, Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 and the intravascular processing of triglyceride-rich lipoproteins. Journal of internal medicine. 2012; 272(6): 528-40.
Zhang Li, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter, Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(11): 2541-6.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen, Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(37): E2486-95.
Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D, Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. Journal of lipid research. 2012; 53(9): 1920-31.
Gin Peter, Goulbourne Chris N, Adeyo Oludotun, Beigneux Anne P, Davies Brandon S J, Tat Shelly, Voss Constance V, Bensadoun André, Fong Loren G, Young Stephen G, Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1. Human molecular genetics. 2012; 21(13): 2961-72.
Chang Sandy Y, Hudon-Miller Sarah E, Yang Shao H, Jung Hea-Jin, Lee John M, Farber Emily, Subramanian Thangaiah, Andres Douglas A, Spielmann H Peter, Hrycyna Christine A, Young Stephen G, Fong Loren G, Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. Journal of lipid research. 2012; 53(6): 1176-82.
Young Stephen G, Jung Hea-Jin, Coffinier Catherine, Fong Loren G, Understanding the roles of nuclear A- and B-type lamins in brain development. The Journal of biological chemistry. 2012; 287(20): 16103-10.
Young Stephen G, Fong Loren G, Lowering plasma cholesterol by raising LDL receptors--revisited. The New England journal of medicine. 2012; 366(12): 1154-5.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G, Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(2): 230-5.
Jung Hea-Jin, Coffinier Catherine, Choe Youngshik, Beigneux Anne P, Davies Brandon S J, Yang Shao H, Barnes Richard H, Hong Janet, Sun Tao, Pleasure Samuel J, Young Stephen G, Fong Loren G, Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(7): E423-31.
Yang Shao H, Chang Sandy Y, Tu Yiping, Lawson Gregory W, Bergo Martin O, Fong Loren G, Young Stephen G, Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. Journal of lipid research. 2012; 53(1): 77-86.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Molecular biology of the cell. 2011; 22(23): 4683-93.
Yang Shao H, Jung Hea-Jin, Coffinier Catherine, Fong Loren G, Young Stephen G, Are B-type lamins essential in all mammalian cells?. Nucleus (Austin, Tex.). 2011; 2(6): 562-9.
Patwari Parth, Emilsson Valur, Schadt Eric E, Chutkow William A, Lee Samuel, Marsili Alessandro, Zhang Yongzhao, Dobrin Radu, Cohen David E, Larsen P Reed, Zavacki Ann Marie, Fong Loren G, Young Stephen G, Lee Richard T, The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell metabolism. 2011; 14(5): 671-83.
Yang Shao H, Chang Sandy Y, Yin Liya, Tu Yiping, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Fong Loren G, Young Stephen G, An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Human molecular genetics. 2011; 20(18): 3537-44.
Scotti Elena, Hong Cynthia, Yoshinaga Yuko, Tu Yiping, Hu Yan, Zelcer Noam, Boyadjian Rima, de Jong Pieter J, Young Stephen G, Fong Loren G, Tontonoz Peter, Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Molecular and cellular biology. 2011; 31(9): 1885-93.
Verstraeten Valerie L R M, Peckham Lana A, Olive Michelle, Capell Brian C, Collins Francis S, Nabel Elizabeth G, Young Stephen G, Fong Loren G, Lammerding Jan, Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(12): 4997-5002.
Yang Shao H, Chang Sandy Y, Ren Shuxun, Wang Yibin, Andres Douglas A, Spielmann H Peter, Fong Loren G, Young Stephen G, Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Human molecular genetics. 2011; 20(3): 436-44.
Gin Peter, Beigneux Anne P, Voss Constance, Davies Brandon S J, Beckstead Jennifer A, Ryan Robert O, Bensadoun André, Fong Loren G, Young Stephen G, Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(1): 176-82.
Davies Brandon Sj, Coffinier Catherine, Yang Shao H, Barnes Richard H, Jung Hea-Jin, Young Stephen G, Fong Loren G, Investigating the purpose of prelamin A processing. Nucleus (Austin, Tex.). 2011; 2(1): 4-9.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G, Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. The Journal of biological chemistry. 2010; 285(50): 39239-48.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G, Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(11): 2106-13.
Coffinier Catherine, Fong Loren G, Young Stephen G, LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins. Nucleus (Austin, Tex.). 2010; 1(5): 407-11.
Davies Brandon S J, Barnes Richard H, Tu Yiping, Ren Shuxun, Andres Douglas A, Spielmann H Peter, Lammerding Jan, Wang Yibin, Young Stephen G, Fong Loren G, An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Human molecular genetics. 2010; 19(13): 2682-94.
Coffinier Catherine, Jung Hea-Jin, Li Ziwei, Nobumori Chika, Yun Ui Jeong, Farber Emily A, Davies Brandon S, Weinstein Michael M, Yang Shao H, Lammerding Jan, Farahani Javad N, Bentolila Laurent A, Fong Loren G, Young Stephen G, Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. The Journal of biological chemistry. 2010; 285(27): 20818-26.
Davies Brandon S J, Beigneux Anne P, Barnes Richard H, Tu Yiping, Gin Peter, Weinstein Michael M, Nobumori Chika, Nyrén Rakel, Goldberg Ira, Olivecrona Gunilla, Bensadoun André, Young Stephen G, Fong Loren G, GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell metabolism. 2010; 12(1): 42-52.
Lee Roger, Chang Sandy Y, Trinh Hung, Tu Yiping, White Andrew C, Davies Brandon S J, Bergo Martin O, Fong Loren G, Lowry William E, Young Stephen G, Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Human molecular genetics. 2010; 19(8): 1603-17.
Coffinier Catherine, Chang Sandy Y, Nobumori Chika, Tu Yiping, Farber Emily A, Toth Julia I, Fong Loren G, Young Stephen G, Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(11): 5076-81.
Yang Shao H, Chang Sandy Y, Andres Douglas A, Spielmann H Peter, Young Stephen G, Fong Loren G, Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. Journal of lipid research. 2010; 51(2): 400-5.
Chan Lai N, Hart Courtenay, Guo Lea, Nyberg Tamara, Davies Brandon S J, Fong Loren G, Young Stephen G, Agnew Brian J, Tamanoi Fuyuhiko, A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis. 2009; 30(20): 3598-606.
Im Seung-Soon, Hammond Linda E, Yousef Leyla, Nugas-Selby Cherryl, Shin Dong-Ju, Seo Young-Kyo, Fong Loren G, Young Stephen G, Osborne Timothy F, Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2. Molecular and cellular biology. 2009; 29(17): 4864-72.
Fong Loren G, Vickers Timothy A, Farber Emily A, Choi Christine, Yun Ui Jeong, Hu Yan, Yang Shao H, Coffinier Catherine, Lee Roger, Yin Liya, Davies Brandon S J, Andres Douglas A, Spielmann H Peter, Bennett C Frank, Young Stephen G, Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Human molecular genetics. 2009; 18(13): 2462-71.
Worman Howard J, Fong Loren G, Muchir Antoine, Young Stephen G, Laminopathies and the long strange trip from basic cell biology to therapy. The Journal of clinical investigation. 2009; 119(7): 1825-36.
Yang Shao H, Bergo Martin O, Farber Emily, Qiao Xin, Fong Loren G, Young Stephen G, Caution! Analyze transcripts from conditional knockout alleles. Transgenic research. 2009; 18(3): 483-9.
Davies Brandon S J, Fong Loren G, Yang Shao H, Coffinier Catherine, Young Stephen G, The posttranslational processing of prelamin A and disease. Annual review of genomics and human genetics. 2009; 10(3): 153-74.
Davies Brandon S J, Yang Shao H, Farber Emily, Lee Roger, Buck Suzanne B, Andres Douglas A, Spielmann H Peter, Agnew Brian J, Tamanoi Fuyuhiko, Fong Loren G, Young Stephen G, Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. Journal of lipid research. 2009; 50(1): 126-34.
Weinstein Michael M, Yin Liya, Beigneux Anne P, Davies Brandon S J, Gin Peter, Estrada Kristine, Melford Kristan, Bishop Joseph R, Esko Jeffrey D, Dallinga-Thie Geesje M, Fong Loren G, Bensadoun André, Young Stephen G, Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. The Journal of biological chemistry. 2008; 283(50): 34511-8.
Davies Brandon S J, Waki Hironori, Beigneux Anne P, Farber Emily, Weinstein Michael M, Wilpitz Damien C, Tai Li-Jung, Evans Ronald M, Fong Loren G, Tontonoz Peter, Young Stephen G, The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Molecular endocrinology (Baltimore, Md.). 2008; 22(11): 2496-504.
Yang Shao H, Andres Douglas A, Spielmann H Peter, Young Stephen G, Fong Loren G, Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. The Journal of clinical investigation. 2008; 118(10): 3291-300.