Dr. Rachelle Crosbie-Watson holds a joint appointment as a Professor in the Department of Integrative Biology and Physiology and the Department of Neurology at UCLA. She is Chair of the M.S. graduate program in Physiological Science and is a Faculty Advisor for the Howard Hughes Undergraduate Research Scholars Program, Regents Scholars Program, and the Beckman Undergraduate Research Scholars Program. She served as Vice-Chair for Integrative Biology and Physiology (2009-2010). Dr. Crosbie-Watson has created a course at UCLA using a new teaching format that is focused entirely on mechanisms and therapies for Duchenne muscular dystrophy. In 2013, Dr. Crosbie-Watson received the UCLA Distinguished Teaching Award, which is a campus-wide recognition of her contributions to education. As Education Liaison, Dr. Crosbie-Watson is developing a graduate program focused on Muscle Cell Biology with an emphasis on translational research. Dr. Crosbie-Watson has expertise on structure and function of the dystrophin- and utrophin-glycoprotein complexes. Her research has revealed novel and unexpected targets in the disease pathway of Duchenne muscular dystrophy. Dr. Crosbie-Watson discovered that introduction of the sarcospan gene into muscles prevents disease in animal models of muscular dystrophy. She is currently translating these preclinical data using a gene therapy approach. She brings knowledge and experience in muscle cell biology to the Executive Committee, and she is a liaison between the graduate training programs on campus and Center activities.
Rutkowski Anne, Bonnemann Carsten, Brown Susan, Thorsteinsdattir Salveig, Dominov Janice, Ruegg Markus A, Matter Michelle L, Guttridge Denis, Crosbie-Watson Rachelle H, Kardon Gabrielle, Nagaraju Kanneboyina, Girgenrath Mahasweta, Burkin Dean J,
Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA
Neuromusc. Dis. : NMD.
Merveille Anne-Christine, Davis Erica E, Becker-Heck Anita, Legendre Marie, Amirav Israel, Bataille GÃ©raldine, Belmont John, Beydon Nicole, Billen FrÃ©dÃ©ric, ClÃ©ment Annick, Clercx CÃ©cile, Coste AndrÃ©, Crosbie Rachelle, de Blic Jacques, Deleuze Stephane, Duquesnoy Philippe, Escalier Denise, Escudier Estelle, Fliegauf Manfred, Horvath Judith, Hill Kent, Jorissen Mark, Just Jocelyne, Kispert Andreas, Lathrop Mark, Loges Niki Tomas, Marthin June K, Momozawa Yukihide, Montantin Guy, Nielsen Kim G, Olbrich Heike, Papon Jean-FranÃ§ois, Rayet Isabelle, Roger Gilles, Schmidts Miriam, Tenreiro Henrique, Towbin Jeffrey A, Zelenika Diana, Zentgraf Hanswalter, Georges Michel, LequarrÃ© Anne-Sophie, Katsanis Nicholas, Omran Heymut, Amselem Serge,
CCDC39 is required for assembly of inner dynein arms and the dynein
regulatory complex and for normal ciliary motility in humans and dogs
Kim Michelle H, Kay Danielle I, Rudra Renuka T, Chen Bo Ming, Hsu Nigel, Izumiya Yasuhiro, Martinez Leonel, Spencer Melissa J, Walsh Kenneth, Grinnell Alan D, Crosbie Rachelle H,
Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice
Hum. Mol. Genet.
Peter Angela K, Ko Christopher Y, Kim Michelle H, Hsu Nigel, Ouchi Noriyuki, Rhie Suhn, Izumiya Yasuhiro, Zeng Ling, Walsh Kenneth, Crosbie Rachelle H,
Myogenic Akt signaling upregulates the utrophin-glycoprotein complex
and promotes sarcolemma stability in muscular dystrophy
Human molecular genetics.
Crawford GC, Faulkner JA, Crosbie RH, Campbell KP, Froehner SC, Chamberlain JS,
Assembly of the Dystrophin Associated Protein Complex Does Not Require the Dystrophin C-terminal Domain.
J. Cell Biol.
News and Views: NO Vascular Control in Duchenne Muscular Dystrophy.
Crosbie RH, Lebakken CS, Holt KH, Venzke DP, Straub V, Lee JC, Grady RM, Chamberlain JS, Sanes JR, Campbell KP,
Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex
J. Cell Biol. .
Crosbie RH, Yamada H, Venzke DP, Lisanti MP, Campbell KP,
Caveolin-3 is Not an Integral Component of the Dystrophin-Glycoprotein Complex.
Duclos F, Straub V, Moore SA, Venzke DP, Hrstka RF, Crosbie RH, Durbeej M, Lebakken CS, Ettinger AJ, van der Meulen J, Holt KH, Lim LE, Sanes JR, Davidson BL, Faulkner JA, Williamson R, Campbell KP,
Progressive Muscular Dystrophy in alpha-Sarcoglycan Deficient Mice.
J. Cell Biol.
Crosbie RH, Heighway J, Venzke DP, Lee JC, Campbell KP,
Sarcospan: The 25kDa Transmembrane Component of the Dystrophin-Glycoprotein Complex.
J. Biol. Chem.
Campbell KP, Crosbie RH,
NEWS AND VIEWS: Utrophin to the Rescue.