Directory

Rachelle H. Crosbie-Watson, Ph.D. [ Edit Your Profile ]

Email Address: rcrosbie@physci.ucla.edu

Lab Number: (310) 794-2107
Office Phone Number: (310) 794-2103

Work Address:
Dept. Integrative Biology & Physiology
610 Charles E Young Drive East
Los Angeles, CA 90095 610 Charles E Young Dr East
Dept Integrative Biology & Physiology
Los Angeles, CA 90095

Work
Position/Title
Professor, Integrative Biology and Physiology, Neurology, Brain Research Institute
Education Liaison, Center for Duchenne Muscular Dystrophy
Member, Cell & Developmental Biology GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area, Molecular, Cellular & Integrative Physiology GPB Home Area

Education:
Degrees:
B.S., Texas A&M University
Ph.D., UCLA

About

Dr. Rachelle Crosbie-Watson holds a joint appointment as a Professor in the Department of Integrative Biology and Physiology and the Department of Neurology at UCLA. She is Chair of the M.S. graduate program in Physiological Science and is a Faculty Advisor for the Howard Hughes Undergraduate Research Scholars Program, Regents Scholars Program, and the Beckman Undergraduate Research Scholars Program. She served as Vice-Chair for Integrative Biology and Physiology (2009-2010). Dr. Crosbie-Watson has created a course at UCLA using a new teaching format that is focused entirely on mechanisms and therapies for Duchenne muscular dystrophy. In 2013, Dr. Crosbie-Watson received the “UCLA Distinguished Teaching Award”, which is a campus-wide recognition of her contributions to education. As Education Liaison, Dr. Crosbie-Watson is developing a graduate program focused on Muscle Cell Biology with an emphasis on translational research. Dr. Crosbie-Watson has expertise on structure and function of the dystrophin- and utrophin-glycoprotein complexes. Her research has revealed novel and unexpected targets in the disease pathway of Duchenne muscular dystrophy. Dr. Crosbie-Watson discovered that introduction of the sarcospan gene into muscles prevents disease in animal models of muscular dystrophy. She is currently translating these preclinical data using a gene therapy approach. She brings knowledge and experience in muscle cell biology to the Executive Committee, and she is a liaison between the graduate training programs on campus and Center activities.

Publications
Marshall Jamie L, Crosbie-Watson Rachelle H, Sarcospan: a small protein with large potential for Duchenne muscular dystrophy. Skeletal Muscle. 2013; 3(1): 1.
Marshall Jamie L, Kwok Yukwah, McMorran Brian J, Baum Linda G, Crosbie-Watson Rachelle H, The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. The FEBS journal. 2013; 280(17): 4210-29.
Marshall Jamie L, Chou Eric, Oh Jennifer, Kwok Allan, Burkin Dean J, Crosbie-Watson Rachelle H, Dystrophin and utrophin expression require sarcospan: loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice. Hum. Mol. Genet. 2012; .
Cabrera Paula V, Pang Mabel, Marshall Jamie L, Kung Raymond, Nelson Stanley F, Stalnaker Stephanie H, Wells Lance, Crosbie-Watson Rachelle H, Baum Linda G, High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regulating sarcolemmal protein abundance and laminin binding. J. Biol. Chem. 2012; 287(27): 22759-70.
Rutkowski Anne, Bonnemann Carsten, Brown Susan, Thorsteinsdattir Salveig, Dominov Janice, Ruegg Markus A, Matter Michelle L, Guttridge Denis, Crosbie-Watson Rachelle H, Kardon Gabrielle, Nagaraju Kanneboyina, Girgenrath Mahasweta, Burkin Dean J, Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA. Neuromusc. Dis. : NMD. 2012; .
Marshall Jamie L, Holmberg Johan, Chou Eric, Ocampo Amber C, Oh Jennifer, Lee Joy, Peter Angela K, Martin Paul T, Crosbie-Watson Rachelle H, Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration. J. Cell Biol. 2012; 197(7): 1009-27.
Merveille Anne-Christine, Davis Erica E, Becker-Heck Anita, Legendre Marie, Amirav Israel, Bataille Géraldine, Belmont John, Beydon Nicole, Billen Frédéric, Clément Annick, Clercx Cécile, Coste André, Crosbie Rachelle, de Blic Jacques, Deleuze Stephane, Duquesnoy Philippe, Escalier Denise, Escudier Estelle, Fliegauf Manfred, Horvath Judith, Hill Kent, Jorissen Mark, Just Jocelyne, Kispert Andreas, Lathrop Mark, Loges Niki Tomas, Marthin June K, Momozawa Yukihide, Montantin Guy, Nielsen Kim G, Olbrich Heike, Papon Jean-François, Rayet Isabelle, Roger Gilles, Schmidts Miriam, Tenreiro Henrique, Towbin Jeffrey A, Zelenika Diana, Zentgraf Hanswalter, Georges Michel, Lequarré Anne-Sophie, Katsanis Nicholas, Omran Heymut, Amselem Serge, CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. Nature genetics. 2011; 43(1): 72-8.
Kim Michelle H, Kay Danielle I, Rudra Renuka T, Chen Bo Ming, Hsu Nigel, Izumiya Yasuhiro, Martinez Leonel, Spencer Melissa J, Walsh Kenneth, Grinnell Alan D, Crosbie Rachelle H, Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Hum. Mol. Genet. 2011; 20(7): 1324-38.
Solares-Pérez Alhondra, Alvarez Rocío, Crosbie Rachelle H, Vega-Moreno Jesús, Medina-Monares Joel, Estrada Francisco J, Ortega Alicia, Coral-Vazquez Ramón, Altered calcium pump and secondary deficiency of gamma-sarcoglycan and microspan in sarcoplasmic reticulum membranes isolated from delta-sarcoglycan knockout mice. Cell calcium. 2010; 48(1): 28-36.
Nelson Stanley F, Crosbie Rachelle H, Miceli M Carrie, Spencer Melissa J, Emerging genetic therapies to treat Duchenne muscular dystrophy. Current opinion in neurology. 2009; 22(5): 532-8.
Peter Angela K, Ko Christopher Y, Kim Michelle H, Hsu Nigel, Ouchi Noriyuki, Rhie Suhn, Izumiya Yasuhiro, Zeng Ling, Walsh Kenneth, Crosbie Rachelle H, Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Human molecular genetics. 2009; 18(2): 318-27.
Peter Angela K, Marshall Jamie L, Crosbie Rachelle H, Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex. The Journal of cell biology. 2008; 183(3): 419-27.
Bekker Janine M, Colantonio Jessica R, Stephens Andrew D, Clarke W Thomas, King Stephen J, Hill Kent L, Crosbie Rachelle H, Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. Cell motility and the cytoskeleton. 2007; 64(6): 461-73.
Peter Angela K, Miller Gaynor, Crosbie Rachelle H, Disrupted mechanical stability of the dystrophin-glycoprotein complex causes severe muscular dystrophy in sarcospan transgenic mice. Journal of cell science. 2007; 120(Pt 6): 996-1008.
Miller Gaynor, Wang Emily L, Nassar Karin L, Peter Angela K, Crosbie Rachelle H, Structural and functional analysis of the sarcoglycan-sarcospan subcomplex. Experimental cell research. 2007; 313(4): 639-51.
Colantonio Jessica R, Bekker Janine M, Kim Sarah J, Morrissey Kari M, Crosbie Rachelle H, Hill Kent L, Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus. Traffic (Copenhagen, Denmark). 2006; 7(5): 538-48.
Peter Angela K, Crosbie Rachelle H, Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway. Experimental cell research. 2006; 312(13): 2580-91.
Miller Gaynor, Peter Angela K, Espinoza Erica, Heighway Jim, Crosbie Rachelle H, Over-expression of Microspan, a novel component of the sarcoplasmic reticulum, causes severe muscle pathology with triad abnormalities. Journal of muscle research and cell motility. 2006; 27(8): 545-58.
Yi Christopher E, Bekker Janine M, Miller Gaynor, Hill Kent L, Crosbie Rachelle H, Specific and potent RNA interference in terminally differentiated myotubes. The Journal of biological chemistry. 2003; 278(2): 934-9.
Crosbie Rachelle H, Dovico Sherri A, Flanagan Jason D, Chamberlain Jeffrey S, Ownby Charlotte L, Campbell Kevin P, Characterization of aquaporin-4 in muscle and muscular dystrophy. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002; 16(9): 943-9.
Crosbie RH, Dovico SA, Flanagan JD, Chamberlain JS, Ownby CL, Campbell KP, Characterization of aquaporin-4 in muscle and muscular dystrophy. FASEB J. . 2002; 16(9): 943-9.
Crosbie Rachelle H, Barresi Rita, Campbell Kevin P, Loss of sarcolemma nNOS in sarcoglycan-deficient muscle. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002; 16(13): 1786-91.
Crawford GC, Faulkner JA, Crosbie RH, Campbell KP, Froehner SC, Chamberlain JS, Assembly of the Dystrophin Associated Protein Complex Does Not Require the Dystrophin C-terminal Domain. J. Cell Biol. 2000; 150: 1411-1422.
Holt KH, Crosbie RH, Venzke DP, Campbell KP, Biosynthesis of dystroglycan: processing of a precursor propeptide. FEBS letters. . 2000; 468(1): 79-83.
Crosbie RH, News and Views: NO Vascular Control in Duchenne Muscular Dystrophy. Nature Med. 2000; 7: 27-29.
Crosbie RH, Lebakken CS, Holt KH, Venzke DP, Straub V, Lee JC, Grady RM, Chamberlain JS, Sanes JR, Campbell KP, Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. J. Cell Biol. . 1999; 145(1): 153-65.
Crosbie RH, Yamada H, Venzke DP, Lisanti MP, Campbell KP, Caveolin-3 is Not an Integral Component of the Dystrophin-Glycoprotein Complex. FEBS Lett. 1998; 427: 279-282.
Duclos F, Straub V, Moore SA, Venzke DP, Hrstka RF, Crosbie RH, Durbeej M, Lebakken CS, Ettinger AJ, van der Meulen J, Holt KH, Lim LE, Sanes JR, Davidson BL, Faulkner JA, Williamson R, Campbell KP, Progressive Muscular Dystrophy in alpha-Sarcoglycan Deficient Mice. J. Cell Biol. 1998; 142: 1461-1471.
Crosbie RH, Straub V, Yun HY, Lee JC, Rafael JA, Chamberlain JS, Dawson VL, Dawson TM, Campbell KP, mdx muscle pathology is independent of nNOS perturbation. Hum. Mol. Genet. 1998; 7(5): 823-9.
Crosbie RH, Heighway J, Venzke DP, Lee JC, Campbell KP, Sarcospan: The 25kDa Transmembrane Component of the Dystrophin-Glycoprotein Complex. J. Biol. Chem. 1997; 272: 31221-31224.
Campbell KP, Crosbie RH, NEWS AND VIEWS: Utrophin to the Rescue. Nature. 1996; 384: 308-309.
Crosbie RH, Chalovich JM, Reisler E, Flexation of caldesmon: effect of conformation on the properties of caldesmon. J. Muscle Res. Cell Mot. . 1995; 16(5): 509-18.
Crosbie RH, Miller C, Chalovich JM, Rubenstein PA, Reisler E, Caldesmon, N-terminal yeast actin mutants, and the regulation of actomyosin interactions. Biochemistry. . 1994; 33(11): 3210-6.
Crosbie RH, Miller C, Cheung P, Goodnight T, Muhlrad A, Reisler E, Structural connectivity in actin: effect of C-terminal modifications on the properties of actin. Biophysical J. . 1994; 67(5): 1957-64.
Crosbie RH, Chalovich JM, Reisler E, Interaction of caldesmon and myosin subfragment 1 with the C-terminus of actin. Biochem. Biophys. Res. Comm. . 1992; 184(1): 239-45.
Crosbie R, Adams S, Chalovich JM, Reisler E, The interaction of caldesmon with the COOH terminus of actin. J. Biol. Chem. . 1991; 266(30): 20001-6.