Directory

Nestor Gonzalez-Cadavid, Ph.D. [ Edit Your Profile ]

Email Address: ncadavid@ucla.edu

Fax Number: 310-222-1914
Work Phone Number: (310) 222-3824
(310)-222-3810

Mailing Address:
BOX 951768, 1000 W Carson St
Torrance, CA 90502

Office Address:
1124 W Carson St.
Bldg. F-6
Torrance, CA 90502

Work
Position/Title
Professor, SURGERY, Internal Medicine
Member, CTSI, Center for Duchenne Muscular Dystrophy
Adjunct Professor, Harbor UCLA Medical Center, Urology

Education:
Degrees:
Ph.D., University of London, England, 1964 - 1967
Ph.D., University of Buenos Aires, Argentina, 1961 - 1964
M.S., University of Buenos Aires, Argentina, 1957 - 1961

Publications
Tsao James, Vernet Dolores A, Gelfand Robert, Kovanecz Istvan, Nolazco Gaby, Bruhn Kevin W, Gonzalez-Cadavid Nestor F, Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle. Stem cell research & therapy. 2013; 4(1): 4.
Ferrini Monica G, Moon Joanne, Rivera Steve, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-β1 therapies in inducible nitric oxide synthase-deficient mice. BJU international. 2012; 109(4): 586-93.
Wang Judy Sc, Kovanecz Istvan, Vernet Dolores, Nolazco Gaby, Kopchok George E, Chow Sheryl L, White Rodney A, Gonzalez-Cadavid Nestor F, Effects of sildenafil and/or muscle derived stem cells on myocardial infarction. Journal of translational medicine. 2012; 10(11): 159.
Kovanecz Istvan, Rivera Steve, Nolazco Gaby, Vernet Dolores, Segura Denesse, Gharib Sahir, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. The journal of sexual medicine. 2012; 9(11): 2814-26.
Toblli Jorge E, Cao Gabriel, Giani Jorge F, Angerosa Margarita, Dominici Fernando P, Gonzalez-Cadavid Nestor F, Antifibrotic effects of pioglitazone at low doses on the diabetic rat kidney are associated with the improvement of markers of cell turnover, tubular and endothelial integrity, and angiogenesis. Kidney & blood pressure research. 2011; 34(1): 20-33.
Ferrini Monica G, Rivera Steve, Moon Joanne, Vernet Dolores, Rajfer Jacob, Gonzalez-Cadavid Nestor F, The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes. The journal of sexual medicine. 2010; 7(9): 3033-44.
Ralph David, Gonzalez-Cadavid Nestor, Mirone Vincenzo, Perovic Sava, Sohn Michael, Usta Mustafa, Levine Laurence, The management of Peyronie's disease: evidence-based 2010 guidelines. The journal of sexual medicine. 2010; 7(7): 2359-74.
Ralph David, Gonzalez-Cadavid Nestor, Mirone Vincenzo, Perovic Sava, Sohn Michael, Usta Mustafa, Levine Laurence, Trauma, gender reassignment, and penile augmentation. The journal of sexual medicine. 2010; 7(4 Pt 2): 1657-67.
Gonzalez-Cadavid Nestor F, Rajfer Jacob, Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy. Nature reviews. Urology. 2010; 7(4): 215-21.
Toblli Jorge E, Ferrini Monica G, Cao Gabriel, Vernet Dolores, Angerosa Margarita, Gonzalez-Cadavid Nestor F, Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009; 24(8): 2384-91.
Kovanecz Istvan, Nolazco Gaby, Ferrini Monica G, Toblli Jorge E, Heydarkhan Sanaz, Vernet Dolores, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction. BJU international. 2009; 103(10): 1396-404.
Gonzalez-Cadavid Nestor F, Rajfer Jacob, Experimental models of Peyronie's disease. Implications for new therapies. The journal of sexual medicine. 2009; 6(2): 303-13.
Ferrini Monica G, Kovanecz Istvan, Sanchez Sandra, Umeh Chiome, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. The journal of sexual medicine. 2009; 6(2): 415-28.
Gonzalez-Cadavid Nestor F, Mechanisms of penile fibrosis. The journal of sexual medicine. 2009; 6 Suppl 3(10): 353-62.
Ho Matthew H, Heydarkhan Sanaz, Vernet Dolores, Kovanecz Istvan, Ferrini Monica G, Bhatia Narender N, Gonzalez-Cadavid Nestor F, Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds. Obstetrics and gynecology. 2009; 114(2 Pt 1): 300-9.
Kovanecz Istvan, Rambhatla Amarnath, Ferrini Monica G, Vernet Dolores, Sanchez Sandra, Rajfer Jacob, Gonzalez-Cadavid Nestor, Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection. BJU international. 2008; 101(2): 203-10.
Nolazco Gaby, Kovanecz Istvan, Vernet Dolores, Gelfand Robert A, Tsao James, Ferrini Monica G, Magee Thomas, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat. BJU international. 2008; 101(9): 1156-64.
Braga Melissa, Sinha Hikim Amiya P, Datta Sanjit, Ferrini Monica G, Brown Danielle, Kovacheva Ekaterina L, Gonzalez-Cadavid Nestor F, Sinha-Hikim Indrani, Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis : an international journal on programmed cell death. 2008; 13(6): 822-32.
Artaza Jorge N, Singh Rajan, Ferrini Monica G, Braga Melissa, Tsao James, Gonzalez-Cadavid Nestor F, Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts. The Journal of endocrinology. 2008; 196(2): 235-49.
Cantini Liliana P, Ferrini Monica G, Vernet Dolores, Magee Thomas R, Qian Ansha, Gelfand Robert A, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Profibrotic role of myostatin in Peyronie's disease. The journal of sexual medicine. 2008; 5(7): 1607-22.
Kovanecz Istvan, Ferrini Monica G, Vernet Dolores, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone. BJU international. 2007; 100(4): 867-74.
Artaza Jorge N, Reisz-Porszasz Suzanne, Dow Joan S, Kloner Robert A, Tsao James, Bhasin Shalender, Gonzalez-Cadavid Nestor F, Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. The Journal of endocrinology. 2007; 194(1): 63-76.
Magee Thomas R, Kovanecz Istvan, Davila Hugo H, Ferrini Monica G, Cantini Liliana, Vernet Dolores, Zuniga Freddi I, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. The journal of sexual medicine. 2007; 4(3): 633-43.
Rajfer Jacob, Gore John L, Kaufman Jeffrey, Gonzalez-Cadavid Nestor, Case report: Avoidance of palpable corporal fibrosis due to priapism with upregulators of nitric oxide. The journal of sexual medicine. 2006; 3(1): 173-6.
Ferrini Monica G, Kovanecz Istvan, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease. BJU international. 2006; 97(3): 625-33.
Ferrini Monica G, Nolazco Gaby, Vernet Dolores, Gonzalez-Cadavid Nestor F, Berman Jennifer, Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis. Fertility and sterility. 2006; 86(4 Suppl): 1152-63.
Magee Thomas R, Artaza Jorge N, Ferrini Monica G, Vernet Dolores, Zuniga Freddi I, Cantini Liliana, Reisz-Porszasz Suzanne, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass. The journal of gene medicine. 2006; 8(9): 1171-81.
Vernet Dolores, Magee Thomas, Qian Ansha, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor, Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells. The journal of sexual medicine. 2006; 3(1): 84-94; discussion 94-5.
Kovanecz Istvan, Ferrini Monica G, Vernet Dolores, Nolazco Gaby, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus. BJU international. 2006; 98(1): 116-24.
Ferrini Monica G, Davila Hugo H, Kovanecz Istvan, Sanchez Sandra P, Gonzalez-Cadavid Nestor F, Rajfer Jacob, Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology. 2006; 68(2): 429-35.
Jack Gregory S, Gonzalez-Cadavid Nestor, Rajfer Jacob, Conservative management options for Peyronie's disease. Current urology reports. 2005; 6(6): 454-60.
Jasuja Ravi, Ramaraj Pandurangan, Mac Ricky Phong, Singh Atam B, Storer Thomas W, Artaza Jorge, Miller Aria, Singh Rajan, Taylor Wayne E, Lee Martin L, Davidson Tina, Sinha-Hikim Indrani, Gonzalez-Cadavid Nestor, Bhasin Shalender, Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men. The Journal of clinical endocrinology and metabolism. 2005; 90(2): 855-63.
Vernet Dolores, Nolazco Gaby, Cantini Liliana, Magee Thomas R, Qian Ansha, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Biology of reproduction. 2005; 73(6): 1199-210.
Hikim Amiya P Sinha, Vera Yanira, Vernet Dolores, Castanares Mark, Diaz-Romero Maruja, Ferrini Monica, Swerdloff Ronald S, Gonzalez-Cadavid Nestor F, Wang Christina, Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats. The journals of gerontology. Series A, Biological sciences and medical sciences. 2005; 60(6): 702-8.
Gonzalez-Cadavid Nestor F, Rajfer Jacob, Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease. Nature clinical practice. Urology. 2005; 2(6): 291-7.
Artaza Jorge N, Bhasin Shalender, Magee Thomas R, Reisz-Porszasz Suzanne, Shen Ruoquin, Groome Nigel P, Meerasahib Mohamed Fareez, Fareez Meerasaluh M, Gonzalez-Cadavid Nestor F, Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology. 2005; 146(8): 3547-57.
Sáenz de Tejada Iñigo, Angulo Javier, Cellek Selim, González-Cadavid Nestor, Heaton Jeremy, Pickard Robert, Simonsen Ulf, Pathophysiology of erectile dysfunction. The journal of sexual medicine. 2005; 2(1): 26-39.
Davila Hugo H, Magee Thomas R, Zuniga Freddi I, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaque. Urology. 2005; 65(4): 645-8.
Ferrini Monica G, Davila Hugo H, Valente Eliane G A, Gonzalez-Cadavid Nestor F, Rajfer Jacob, Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovascular research. 2004; 61(4): 796-805.
Sinha-Hikim Indrani, Taylor Wayne E, Gonzalez-Cadavid Nestor F, Zheng Wei, Bhasin Shalender, Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. The Journal of clinical endocrinology and metabolism. 2004; 89(10): 5245-55.
Davila Hugo H, Magee Thomas R, Vernet Dolores, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease. Biology of reproduction. 2004; 71(5): 1568-77.
Jalkut Mark, Gonzalez-Cadavid Nestor, Rajfer Jacob, New discoveries in the basic science understanding of Peyronie's disease. Current urology reports. 2004; 5(6): 478-84.
Sáenz de Tejada Iñigo, Angulo Javier, Cellek Selim, González-Cadavid Nestor, Heaton Jeremy, Pickard Robert, Simonsen Ulf, Physiology of erectile function. The journal of sexual medicine. 2004; 1(3): 254-65.
Gonzalez-Cadavid Nestor F, Bhasin Shalender, Role of myostatin in metabolism. Current opinion in clinical nutrition and metabolic care. 2004; 7(4): 451-7.
Gonzalez-Cadavid Nestor F, Rajfer Jacob, Therapy of erectile dysfunction: potential future treatments. Endocrine. 2004; 23(2-3): 167-76.
Singh Rajan, Artaza Jorge N, Taylor Wayne E, Gonzalez-Cadavid Nestor F, Bhasin Shalender, Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology. 2003; 144(11): 5081-8.
Berman Jennifer R, Almeida Fernando G, Jolin Julie, Raz Shlomo, Chaudhuri Gautam, Gonzalez-Cadavid Nestor F, Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status. Fertility and sterility. 2003; 79(4): 925-31.
Ma Kun, Mallidis Con, Bhasin Shalender, Mahabadi Vahid, Artaza Jorge, Gonzalez-Cadavid Nestor, Arias Jose, Salehian Behrouz, Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. American journal of physiology. Endocrinology and metabolism. 2003; 285(2): E363-71.
Valente Eliane G A, Vernet Dolores, Ferrini Monica G, Qian Ansha, Rajfer Jacob, Gonzalez-Cadavid Nestor F, L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 2003; 9(4): 229-44.
Reisz-Porszasz Suzanne, Bhasin Shalender, Artaza Jorge N, Shen Ruoqing, Sinha-Hikim Indrani, Hogue Aimee, Fielder Thomas J, Gonzalez-Cadavid Nestor F, Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin. American journal of physiology. Endocrinology and metabolism. 2003; 285(4): E876-88.
Liu Wei, Thomas Scott G, Asa Sylvia L, Gonzalez-Cadavid Nestor, Bhasin Shalendar, Ezzat Shereen, Myostatin is a skeletal muscle target of growth hormone anabolic action. The Journal of clinical endocrinology and metabolism. 2003; 88(11): 5490-6.
Ferrini Monica G, Magee Thomas R, Vernet Dolores, Rajfer Jacob, González-Cadavid Nestor F, Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection. The Journal of comparative neurology. 2003; 458(1): 46-61.
Jalkut Mark, Gonzalez-Cadavid Nestor, Rajfer Jacob, Peyronie's Disease: A Review. Reviews in urology. 2003; 5(3): 142-8.
Gholami Shahram S, Gonzalez-Cadavid Nestor F, Lin Ching-Shwu, Rajfer Jacob, Lue Tom F, Peyronie's disease: a review. The Journal of urology. 2003; 169(4): 1234-41.
Bhasin Shalender, Taylor Wayne E, Singh Rajan, Artaza Jorge, Sinha-Hikim Indrani, Jasuja Ravi, Choi Helen, Gonzalez-Cadavid Nestor F, The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. The journals of gerontology. Series A, Biological sciences and medical sciences. 2003; 58(12): M1103-10.
Taylor Wayne E, Bhasin Shalender, Lalani Rukhsana, Datta Anuj, Gonzalez-Cadavid Nestor F, Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. 2002; 9(2): 61-70.
Vernet Dolores, Ferrini Monica G, Valente Eliane G, Magee Thomas R, Bou-Gharios George, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society. 2002; 7(4): 262-76.
Artaza Jorge N, Bhasin Shalender, Mallidis Con, Taylor Wayne, Ma Kun, Gonzalez-Cadavid Nestor F, Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells. Journal of cellular physiology. 2002; 190(2): 170-9.
Rajfer Jacob, Magee Thomas, Gonzalez-Cadavid Nestor, Future strategies for treating erectile dysfunction. Reviews in urology. 2002; 4 Suppl 3(2): S48-53.
Magee Thomas R, Qian Ansha, Rajfer Jacob, Sander Fred C, Levine Laurence A, Gonzalez-Cadavid Nestor F, Gene expression profiles in the Peyronie's disease plaque. Urology. 2002; 59(3): 451-7.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biology of reproduction. 2002; 67(3): 1033-41.
Magee Thomas R, Ferrini Monica, Garban Hermes J, Vernet Dolores, Mitani Kohnosuke, Rajfer Jacob, Gonzalez-Cadavid Nestor F, Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biology of reproduction. 2002; 67(1): 20-8.
Wang Christina, Hikim Amiva Sinha, Ferrini Monica, Bonavera Juan J, Vernet Dolores, Leung Andrew, Lue Yan-He, Gonzalez-Cadavid Nestor F, Swerdloff Ronald S, Male reproductive ageing: using the brown Norway rat as a model for man. Novartis Foundation symposium. 2002; 242(2): 82-95; discussion 95-7.
Sinha-Hikim Indrani, Artaza Jorge, Woodhouse Linda, Gonzalez-Cadavid Nestor, Singh Atam B, Lee Martin I, Storer Thomas W, Casaburi Richard, Shen Ruoquing, Bhasin Shalender, Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. American journal of physiology. Endocrinology and metabolism. 2002; 283(1): E154-64.