Yibin Wang, Ph.D. [ Edit Your Profile ]

Work Email Address:
Work Email Address:

Work Phone Number: (310)2065197

Mailing Address:
UCLA, David Geffen School of Medicine
Department of Anesthesiology
Division of Molecular Medicine
650 Charles E Young Dr.
Los Angeles, CA 90095

Work Address:
CHS BH-569
Campus - 711520

Vice-Chair, Research, and Professor, Anesthesiology
Professor, Medicine
Member, California NanoSystems Institute, Cell & Developmental Biology GPB Home Area, Center for Duchenne Muscular Dystrophy, Genetics & Genomics GPB Home Area, JCCC Signal Transduction and Therapeutics Program Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Faculty, Cardiovascular Research Laboratory, Cardiology

Ph.D., Baylor College of Medicine, 1993
B.S., New York State University, 1988 -

Touma, M.; Kang, X.; Zhao, Y.; Cass, A. A.; Gao, F.; Biniwale, R.; Coppola, G.; Xiao, X.; Reemtsen, B.; Wang, Y., Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery. Circ Cardiovasc Genet. 2016; 9(5): 395-407.
Wang, J. J.; Rau, C.; Avetisyan, R.; Ren, S.; Romay, M. C.; Stolin, G.; Gong, K. W.; Wang, Y.; Lusis, A. J., Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 2016; 12(7): e1006038.
Gao, C.; Wang, Y., Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy. Hypertension. 2016; 67(5): 841-2.
Gao, C.; Ren, S.; Lee, J. H.; Qiu, J.; Chapski, D. J.; Rau, C. D.; Zhou, Y.; Abdellatif, M.; Nakano, A.; Vondriska, T. M.; Xiao, X.; Fu, X. D.; Chen, J. N.; Wang, Y., RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2016; 126(1): 195-206.
Lusis, A. J.; Seldin, M. M.; Allayee, H.; Bennett, B. J.; Civelek, M.; Davis, R. C.; Eskin, E.; Farber, C. R.; Hui, S.; Mehrabian, M.; Norheim, F.; Pan, C.; Parks, B.; Rau, C. D.; Smith, D. J.; Vallim, T.; Wang, Y.; Wang, J., The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016; 57(6): 925-42.
Wang, Z.; Zhang, X. J.; Ji, Y. X.; Zhang, P.; Deng, K. Q.; Gong, J.; Ren, S.; Wang, X.; Chen, I.; Wang, H.; Gao, C.; Yokota, T.; Ang, Y. S.; Li, S.; Cass, A.; Vondriska, T. M.; Li, G.; Deb, A.; Srivastava, D.; Yang, H. T.; Xiao, X.; Li, H.; Wang, Y., The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016; 22(10): 1131-1139.
Song, Y.; Zhang, Y.; Jiang, H.; Zhu, Y.; Liu, L.; Feng, W.; Yang, L.; Wang, Y.; Li, M., Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway. FEBS Open Bio. 2015; 5: 656-60.
Rau, C. D.; Lusis, A. J.; Wang, Y., Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015; 30(3): 222-7.
Rau, C. D.; Parks, B.; Wang, Y.; Eskin, E.; Simecek, P.; Churchill, G. A.; Lusis, A. J., High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 2015; 5(10): 2021-6.
Cai, R.; Gu, J.; Sun, H.; Liu, X.; Mei, W.; Qi, Y.; Xue, S.; Ren, S.; Rabinowitz, J. E.; Wang, Y.; Yeh, E. T.; Cheng, J., Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J Mol Cell Cardiol. 2015; 79: 115-22.
Feng, J.; Gong, D.; Fu, X.; Wu, T. T.; Wang, J.; Chang, J.; Zhou, J.; Lu, G.; Wang, Y.; Sun, R., M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production. Sci Rep. 2015; 5: 17228.
Rau, C. D.; Wang, J.; Avetisyan, R.; Romay, M. C.; Martin, L.; Ren, S.; Wang, Y.; Lusis, A. J., Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet. 2015; 8(1): 40-9.
Neelankavil, J.; Rau, C. D.; Wang, Y., The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets. J Cardiothorac Vasc Anesth. 2015; 29(5): 1328-32.
Ren, S.; Lu, G.; Ota, A.; Zhou, Z. H.; Vondriska, T. M.; Lane, T. F.; Wang, Y., IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. PLoS One. 2014; 9(11): e111606.
Sun, H.; Wang, Y., Interferon regulatory factors in heart: stress response beyond inflammation. Hypertension. 2014; 63(4): 663-4.
Lam, M. P.; Wang, D.; Lau, E.; Liem, D. A.; Kim, A. K.; Ng, D. C.; Liang, X.; Bleakley, B. J.; Liu, C.; Tabaraki, J. D.; Cadeiras, M.; Wang, Y.; Deng, M. C.; Ping, P., Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest. 2014; 124(4): 1734-44.
Gao, C.; Wang, Y., Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome. Circ J. 2014; 78(5): 1038-47.
Gupta, A.; Rohlfsen, C.; Leppo, M. K.; Chacko, V. P.; Wang, Y.; Steenbergen, C.; Weiss, R. G., Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity. PLoS One. 2013; 8(10): e74675.
Foster, W. H.; Langenbacher, A.; Gao, C.; Chen, J.; Wang, Y., Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 2013; 242(9): 1101-9.
Lu, G.; Ota, A.; Ren, S.; Franklin, S.; Rau, C. D.; Ping, P.; Lane, T. F.; Zhou, Z. H.; Reue, K.; Lusis, A. J.; Vondriska, T.; Wang, Y., PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol Metab. 2013; 2(4): 405-16.
Li, J.; Umar, S.; Iorga, A.; Youn, J. Y.; Wang, Y.; Regitz-Zagrosek, V.; Cai, H.; Eghbali, M., Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol. 2012; 107(4): 271.
Gao, C.; Wang, Y., Global impact of RNA splicing on transcriptome remodeling in the heart. J Zhejiang Univ Sci B. 2012; 13(8): 603-8.
Ghazalpour, A.; Rau, C. D.; Farber, C. R.; Bennett, B. J.; Orozco, L. D.; van Nas, A.; Pan, C.; Allayee, H.; Beaven, S. W.; Civelek, M.; Davis, R. C.; Drake, T. A.; Friedman, R. A.; Furlotte, N.; Hui, S. T.; Jentsch, J. D.; Kostem, E.; Kang, H. M.; Kang, E. Y.; Joo, J. W.; Korshunov, V. A.; Laughlin, R. E.; Martin, L. J.; Ohmen, J. D.; Parks, B. W.; Pellegrini, M.; Reue, K.; Smith, D. J.; Tetradis, S.; Wang, J.; Wang, Y.; Weiss, J. N.; Kirchgessner, T.; Gargalovic, P. S.; Eskin, E.; Lusis, A. J.; LeBoeuf, R. C., Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012; 23(9-10): 680-92.
Sun, H.; Wang, Y., Novel Ser/Thr protein phosphatases in cell death regulation. Physiology (Bethesda). 2012; 27(1): 43-52.
Franklin, S.; Chen, H.; Mitchell-Jordan, S.; Ren, S.; Wang, Y.; Vondriska, T. M., Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics. 2012; 11(6): M111 014258.
MacLellan, W. R.; Wang, Y.; Lusis, A. J., Systems-based approaches to cardiovascular disease. Nat Rev Cardiol. 2012; 9(3): 172-84.
Foster, W. H.; Tidball, J. G.; Wang, Y., p38gamma activity is required for maintenance of slow skeletal muscle size. Muscle Nerve. 2012; 45(2): 266-73.
Sun, H.; Lu, G.; Ren, S.; Chen, J.; Wang, Y., Catabolism of branched-chain amino acids in heart failure: insights from genetic models. Pediatr Cardiol. 2011; 32(3): 305-10.
Deng, N.; Zhang, J.; Zong, C.; Wang, Y.; Lu, H.; Yang, P.; Wang, W.; Young, G. W.; Wang, Y.; Korge, P.; Lotz, C.; Doran, P.; Liem, D. A.; Apweiler, R.; Weiss, J. N.; Duan, H.; Ping, P., Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria. Mol Cell Proteomics. 2011; 10(2): M110 000117.
Marber, M. S.; Rose, B.; Wang, Y., The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure. J Mol Cell Cardiol. 2011; 51(4): 485-90.
Streicher, J. M.; Kamei, K.; Ishikawa, T. O.; Herschman, H.; Wang, Y., Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. J Mol Cell Cardiol. 2010; 49(1): 88-94.
Otsuka, M.; Kang, Y. J.; Ren, J.; Jiang, H.; Wang, Y.; Omata, M.; Han, J., Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology. 2010; 138(4): 1255-65, 1265 e1-9.
Rose, B. A.; Force, T.; Wang, Y., Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev. 2010; 90(4): 1507-46.
Ahuja, P.; Zhao, P.; Angelis, E.; Ruan, H.; Korge, P.; Olson, A.; Wang, Y.; Jin, E. S.; Jeffrey, F. M.; Portman, M.; Maclellan, W. R., Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest. 2010; 120(5): 1494-505.
Paulsson, A. K.; Franklin, S.; Mitchell-Jordan, S. A.; Ren, S.; Wang, Y.; Vondriska, T. M., Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010; 48(6): 1206-14.
Papanicolaou, K. N.; Streicher, J. M.; Ishikawa, T. O.; Herschman, H.; Wang, Y.; Walsh, K., Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. J Mol Cell Cardiol. 2010; 49(2): 196-209.
Cross, H. R.; Li, M.; Petrich, B. G.; Murphy, E.; Wang, Y.; Steenbergen, C., Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. Acta Physiol Hung. 2009; 96(3): 307-23.
Lu, G.; Sun, H.; Korge, P.; Koehler, C. M.; Weiss, J. N.; Wang, Y., Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. Methods Enzymol. 2009; 457: 255-73.
Ruan, H.; Li, J.; Ren, S.; Gao, J.; Li, G.; Kim, R.; Wu, H.; Wang, Y., Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. J Mol Cell Cardiol. 2009; 46(2): 193-200.
Seimon, T. A.; Wang, Y.; Han, S.; Senokuchi, T.; Schrijvers, D. M.; Kuriakose, G.; Tall, A. R.; Tabas, I. A., Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. J Clin Invest. 2009; 119(4): 886-98.
Andersson, K. B.; Finsen, A. V.; Sjaland, C.; Winer, L. H.; Sjaastad, I.; Odegaard, A.; Louch, W. E.; Wang, Y.; Chen, J.; Chien, K. R.; Sejersted, O. M.; Christensen, G., Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models. Cell Calcium. 2009; 46(3): 219-25.
Andersson, K. B.; Birkeland, J. A.; Finsen, A. V.; Louch, W. E.; Sjaastad, I.; Wang, Y.; Chen, J.; Molkentin, J. D.; Chien, K. R.; Sejersted, O. M.; Christensen, G., Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol. 2009; 47(2): 180-7.
Lu, G.; Sun, H.; She, P.; Youn, J. Y.; Warburton, S.; Ping, P.; Vondriska, T. M.; Cai, H.; Lynch, C. J.; Wang, Y., Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009; 119(6): 1678-87.
Lu, G.; Wang, Y., Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family. Clin Exp Pharmacol Physiol. 2008; 35(2): 107-12.
Streicher, J. M.; Wang, Y., The role of COX-2 in heart pathology. Cardiovasc Hematol Agents Med Chem. 2008; 6(1): 69-79.
Nguyen, C. T.; Lu, Q.; Wang, Y.; Chen, J. N., Zebrafish as a model for cardiovascular development and disease. Drug Discov Today Dis Models. 2008; 5(3): 135-140.
Peter, P. S.; Brady, J. E.; Yan, L.; Chen, W.; Engelhardt, S.; Wang, Y.; Sadoshima, J.; Vatner, S. F.; Vatner, D. E., Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. J Clin Invest. 2007; 117(5): 1335-43.
Ursitti, J. A.; Petrich, B. G.; Lee, P. C.; Resneck, W. G.; Ye, X.; Yang, J.; Randall, W. R.; Bloch, R. J.; Wang, Y., Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase. J Mol Cell Cardiol. 2007; 42(3): 572-81.
Eghbali, M.; Wang, Y.; Toro, L.; Stefani, E., Heart hypertrophy during pregnancy: a better functioning heart?. Trends Cardiovasc Med. 2006; 16(8): 285-91.
Glaser, N. D.; Lukyanenko, Y. O.; Wang, Y.; Wilson, G. M.; Rogers, T. B., JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2006; 291(3): H1183-92.
Liu, J.; Sadoshima, J.; Zhai, P.; Hong, C.; Yang, G.; Chen, W.; Yan, L.; Wang, Y.; Vatner, S. F.; Vatner, D. E., Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J Mol Cell Cardiol. 2006; 41(4): 680-8.
Rehan, V. K.; Wang, Y.; Patel, S.; Santos, J.; Torday, J. S., Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivo. Pediatr Pulmonol. 2006; 41(6): 558-69.
Takimoto, E.; Champion, H. C.; Li, M.; Belardi, D.; Ren, S.; Rodriguez, E. R.; Bedja, D.; Gabrielson, K. L.; Wang, Y.; Kass, D. A., Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med. 2005; 11(2): 214-22.
Wang, G.; Liem, D. A.; Vondriska, T. M.; Honda, H. M.; Korge, P.; Pantaleon, D. M.; Qiao, X.; Wang, Y.; Weiss, J. N.; Ping, P., Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition. Am J Physiol Heart Circ Physiol. 2005; 288(3): H1290-5.
Takimoto, E.; Champion, H. C.; Li, M.; Ren, S.; Rodriguez, E. R.; Tavazzi, B.; Lazzarino, G.; Paolocci, N.; Gabrielson, K. L.; Wang, Y.; Kass, D. A., Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest. 2005; 115(5): 1221-31.
Ren, J.; Zhang, S.; Kovacs, A.; Wang, Y.; Muslin, A. J., Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction. J Mol Cell Cardiol. 2005; 38(4): 617-23.
Zhang, L.; Zhu, H.; Davis, J. J.; Jacob, D.; Wu, S.; Teraishi, F.; Gutierrez, A.; Wang, Y.; Fang, B., Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. Cancer Biol Ther. 2004; 3(3): 296-301.
Zheng, M.; Dilly, K.; Dos Santos Cruz, J.; Li, M.; Gu, Y.; Ursitti, J. A.; Chen, J.; Ross, J., Jr.; Chien, K. R.; Lederer, J. W.; Wang, Y., Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart. Am J Physiol Heart Circ Physiol. 2004; 286(1): H424-33.
Petrich, B. G.; Wang, Y., Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. Trends Cardiovasc Med. 2004; 14(2): 50-5.
Minamisawa, S.; Wang, Y.; Chen, J.; Ishikawa, Y.; Chien, K. R.; Matsuoka, R., Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. J Biol Chem. 2003; 278(11): 9570-5..
Christensen, G.; Gruber, P. J.; Wang, Y.; Chien, K. R., Embryonic and neonatal cardiac gene transfer in vivo. Methods Mol Biol. 2003; 219: 169-78.
Domsic, J. K.; Wang, Y.; Mayeda, A.; Krainer, A. R.; Stoltzfus, C. M., Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts. Mol Cell Biol. 2003; 23(23): 8762-72.
Isoda, T.; Paolocci, N.; Haghighi, K.; Wang, C.; Wang, Y.; Georgakopoulos, D.; Servillo, G.; Della Fazia, M. A.; Kranias, E. G.; Depaoli-Roach, A. A.; Sassone-Corsi, P.; Kass, D. A., Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). FASEB J. 2003; 17(2): 144-51.
Petrich, B. G.; Molkentin, J. D.; Wang, Y., Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination. FASEB J. 2003; 17(6): 749-51.
Zhang, S.; Weinheimer, C.; Courtois, M.; Kovacs, A.; Zhang, C. E.; Cheng, A. M.; Wang, Y.; Muslin, A. J., The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest. 2003; 111(6): 833-41.
Weiss, R. G.; Chatham, J. C.; Georgakopolous, D.; Charron, M. J.; Wallimann, T.; Kay, L.; Walzel, B.; Wang, Y.; Kass, D. A.; Gerstenblith, G.; Chacko, V. P., An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. FASEB J. 2002; 16(6): 613-5.
Hoshijima, M.; Ikeda, Y.; Iwanaga, Y.; Minamisawa, S.; Date, M. O.; Gu, Y.; Iwatate, M.; Li, M.; Wang, L.; Wilson, J. M.; Wang, Y.; Ross, J., Jr.; Chien, K. R., Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002; 8(8): 864-71.
Sotoudeh, M.; Li, Y. S.; Yajima, N.; Chang, C. C.; Tsou, T. C.; Wang, Y.; Usami, S.; Ratcliffe, A.; Chien, S.; Shyy, J. Y., Induction of apoptosis in vascular smooth muscle cells by mechanical stretch. Am J Physiol Heart Circ Physiol. 2002; 282(5): H1709-16.
Petrich, B. G.; Liao, P.; Wang, Y., Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure. Cold Spring Harb Symp Quant Biol. 2002; 67: 429-37..
Wang, Y., Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach. Curr Opin Pharmacol. 2001; 1(2): 134-40.
Wang, I. I.; Huang, I. I., Adenovirus technology for gene manipulation and functional studies. Drug Discov Today. 2000; 5(1): 10-16.
Wang, X.; McGowan, C. H.; Zhao, M.; He, L.; Downey, J. S.; Fearns, C.; Wang, Y.; Huang, S.; Han, J., Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol. 2000; 20(13): 4543-52.
Garcia, G. E.; Xia, Y.; Chen, S.; Wang, Y.; Ye, R. D.; Harrison, J. K.; Bacon, K. B.; Zerwes, H. G.; Feng, L., NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS. J Leukoc Biol. 2000; 67(4): 577-84.
Saurin, A. T.; Martin, J. L.; Heads, R. J.; Foley, C.; Mockridge, J. W.; Wright, M. J.; Wang, Y.; Marber, M. S., The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. FASEB J. 2000; 14(14): 2237-46.
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Minamisawa, S.; Hoshijima, M.; Chu, G.; Ward, C. A.; Frank, K.; Gu, Y.; Martone, M. E.; Wang, Y.; Ross, J., Jr.; Kranias, E. G.; Giles, W. R.; Chien, K. R., Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 1999; 99(3): 313-22.
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Rau, C. D.; Romay, M. C.; Tuteryan, M.; Wang, J. J.; Santolini, M.; Ren, S.; Karma, A.; Weiss, J. N.; Wang, Y.; Lusis, A. J., Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell Syst. 2016; .
Pillai, I. C.; Li, S.; Romay, M.; Lam, L.; Lu, Y.; Huang, J.; Dillard, N.; Zemanova, M.; Rubbi, L.; Wang, Y.; Lee, J.; Xia, M.; Liang, O.; Xie, Y. H.; Pellegrini, M.; Lusis, A. J.; Deb, A., Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell Stem Cell. 2016; .
Dong, W.; Zhou, M.; Dong, M.; Pan, B.; Liu, Y.; Shao, J.; Gu, X.; Huang, Y.; Li, G.; Wang, Y.; Sun, H., Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2016; 101: 90-98.
Franklin, S.; Kimball, T.; Rasmussen, T. L.; Rosa-Garrido, M.; Chen, H.; Tran, T.; Miller, M. R.; Gray, R.; Jiang, S.; Ren, S.; Wang, Y.; Tucker, H. O.; Vondriska, T. M., The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Am J Physiol Heart Circ Physiol. 2016; 311(5): H1234-H1247.
Wang, J. J.; Aboulhosn, J. A.; Hofer, I. S.; Mahajan, A.; Wang, Y.; Vondriska, T. M., Operationalizing Precision Cardiovascular Medicine: Three Innovations. Circ Res. 2016; 119(9): 984-987.
Rau, C. D.; Gao, C.; Wang, Y., Deconvolution of the Human Endothelial Transcriptome. Cell Syst. 2016; 3(3): 218-220.
Sun, H.; Wang, Y., Branched chain amino acid metabolic reprogramming in heart failure. Biochim Biophys Acta. 2016; .
Karbassi, E.; Monte, E.; Chapski, D. J.; Lopez, R.; Rosa Garrido, M.; Kim, J.; Wisniewski, N.; Rau, C. D.; Wang, J. J.; Weiss, J. N.; Wang, Y.; Lusis, A. J.; Vondriska, T. M., Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol Genomics. 2016; 48(8): 601-15.
Monte, E.; Rosa-Garrido, M.; Karbassi, E.; Chen, H.; Lopez, R.; Rau, C. D.; Wang, J.; Nelson, S. F.; Wu, Y.; Stefani, E.; Lusis, A. J.; Wang, Y.; Kurdistani, S. K.; Franklin, S.; Vondriska, T. M., Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem. 2016; 291(30): 15428-46.
Sun, H.; Olson, K. C.; Gao, C.; Prosdocimo, D. A.; Zhou, M.; Wang, Z.; Jeyaraj, D.; Youn, J. Y.; Ren, S.; Liu, Y.; Rau, C. D.; Shah, S.; Ilkayeva, O.; Gui, W. J.; William, N. S.; Wynn, R. M.; Newgard, C. B.; Cai, H.; Xiao, X.; Chuang, D. T.; Schulze, P. C.; Lynch, C.; Jain, M. K.; Wang, Y., Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation. 2016; 133(21): 2038-49.
Cong, Q.; Jia, H.; Biswas, S.; Li, P.; Qiu, S.; Deng, Q.; Guo, X.; Ma, G.; Ling Chau, J. F.; Wang, Y.; Zhang, Z. L.; Jiang, X.; Liu, H.; Li, B., p38alpha MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. Stem Cell Reports. 2016; 6(4): 566-78.
Chen, H.; Orozco, L. D.; Wang, J.; Rau, C. D.; Rubbi, L.; Ren, S.; Wang, Y.; Pellegrini, M.; Lusis, A. J.; Vondriska, T. M., DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ Res. 2016; 118(5): 786-97.
Iorga, A.; Li, J.; Sharma, S.; Umar, S.; Bopassa, J. C.; Nadadur, R. D.; Centala, A.; Ren, S.; Saito, T.; Toro, L.; Wang, Y.; Stefani, E.; Eghbali, M., Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016; 5(1): .
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